Supplementary Figure 6: Y130F, D131Y and Y132D mutations of hA3A narrowed the editing window of hA3A-BE3.
From: Efficient base editing in methylated regions with a human APOBEC3A-Cas9 fusion
Summary of base editing frequencies induced by hA3A-BE3 (a), hA3A-BE3-Y130F (b), hA3A-BE3-D131Y (c) and hA3A-BE3-Y132D (d) on each cytosine in indicated target sites. Cytosines are counted with the base distal to the PAM setting as position 1. These data show that Y130F, D131Y or Y132D mutation on hA3A module narrowed the major editing window (red box).
