Supplementary Figure 2: Comparison of product purities and indel mutation frequencies for BE3 and eA3A-BE3 on endogenous human gene target sites.
From: An APOBEC3A-Cas9 base editor with minimized bystander and off-target activities
(a) Graph showing normalized frequencies of cognate Cs edited to A, T, or G for twelve endogenous human gene target sites from Fig. 1d when targeting with BE3 or A3A (N57G)-BE3. (b) Graph showing indel mutation frequencies for BE3, the YE BE3s, and different engineered A3A-BE3 variants at the same 12 sites shown in (a). All data shown represent the mean of three biological replicates with error bars representing SEMs.
