Supplementary Figure 3: Project Discovery performance relative to HPA v14.

(a) Gamer over-represented co-annotations with solution classes from the HPA Cell Atlas v14 (p<1e-2, one-tailed Binomial test, Bonferroni corrected by row, sample size indicated in parenthesis on each row/column) of gamer predicted labels (columns, blue), with expected co-localization frequencies from HPA v14 (rows, red). Columns with large numbers of significant over co-annotations represent generally over annotated classifications by the gamers (Nucleus, Cytoplasm, Aggresome, Microtubule ends). (b) Proportion of co-annotation in Project Discovery from gamer labels (columns, blue) with HPA Cell Atlas v14 labels (rows, red). Note particularly that novel classes (e.g. nucleoli rim) are co-annotated with their logical parent class (nucleoli) indicating successful refinement of labels.