Supplementary Figure 2: Thrashing phenotypes of candidate Parkinson's disease genes. | Nature Biotechnology

Supplementary Figure 2: Thrashing phenotypes of candidate Parkinson's disease genes.

From: An integrative tissue-network approach to identify and test human disease genes

Supplementary Figure 2

Neuron-sensitive animals (unc-119p::sid-1) were exposed to adult-only RNAi targeting 45 top candidate PD genes, and tested for thrashing defects on days 2, 5, and 8 of adulthood. Movement was analyzed using CeleST. CeleST quantification of thrashing on day 8 is shown. Control L4440 RNAi (blue), direct GWAS worm orthologs (red), and candidates independently identified using the 23andMe GWAS study (yellow) are shown. Mean ± SEM, unpaired two-sided t-test, Benjamini-Hochberg multiple hypothesis test correction, n ≥ 50 per gene (exact sample sizes per gene in Supplementary Data 13). *p<0.05, **p<0.01, ***p<0.001, ****p<0.0001.

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