Most agronomic traits result from the action of several genes, so efficient strategies to express multiple genes in transgenic plants are sorely needed, and not at all trivial undertakings. In this issue, Daniell and colleagues show a way to stably integrate into the chloroplast genome the entire Bt cry2Aa2 operon, which codes for production of an insecticidal protein, as well as accessory proteins to help with folding. The insecticidal protein accumulated to extremely high levels in leaves (∼35% of total soluble protein) in a crystalline form, and insects recalcitrant to other control methods were totally wiped out after munching on leaves from these plants. This successful expression of multiple genes through a single transformation event may make multigene expression of foreign pathways or pharmaceutical proteins less of a chore (see p. 71).