Abstract
A high cephalosporin C producing strain of Cephalosporium acremonium produces higher levels of two enzymes of the bio–synthetic pathway than does a low–producing strain. More importantly, the deacetoxycephalosporin C synthetase of the superior strain appears to be deregulated with respect to carbon source repression. Thus screening or selecting for repression–resistant mutants would appear to be a useful general strategy for obtaining improved antibiotic producers.
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References
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Shen, YQ., Wolfe, S. & Demain, A. Levels of Isopenicillin N Synthetase and Deacetoxycephalosporin C Synthetase in Cephalosporium acremonium Producing High and Low Levels of Cephalosporin C. Nat Biotechnol 4, 61–64 (1986). https://doi.org/10.1038/nbt0186-61
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DOI: https://doi.org/10.1038/nbt0186-61
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