In this issue, Westin and colleagues describe a new method for simultaneous amplification and detection of multiple targets on a single microchip array. They used an electric field to position different oligonucleotides at discrete areas on the microelectronic array, thus preventing nonspecific interactions from occurring between the primer sets. To amplify the target DNA, they used strand displacement amplification (SDA), an isothermal reaction that results in total displacement of the target strand after each amplification reaction. Combining electronic addressing with SDA provides a convenient and flexible platform for a variety of nucleic acid-based assays.