Table 1 Recent patent applications in RNA interference
Patent # | Subject | Assignee(s) | Inventor(s) | Priority application date | Publication date |
|---|---|---|---|---|---|
US 20060240556 | A method of making a nuclear transfer embryo comprising stably transfecting a construct to mediate RNA interference of a target gene or gene transcript expressed in the particular lineage into the cell. | Advanced Cell Technology (Alameda, CA, USA) | Cibelli J | 3/8/2001 | 6/22/2006 |
WO 2006128739 | New oligonucleotide compositions for RNA interference, comprising double-stranded oligonucleotides of identical or different sequences and/or length; useful for inhibiting gene expression for treating cancers or viral infections. | Polyplus-Transfection (Illkirch, France) | Behr J, Bolcato Bellemin A, Erbacher P | 6/1/2005 | 6/1/2006 |
WO 2006128141 | A new double-stranded nucleic acid molecule for treating stromal cell–derived, factor-1–mediated condition (e.g., cancer), comprising a sense strand and an antisense strand with a sequence complementary to the RNA of factor-1, with both having specific nucleotides. | Sirna Therapeutics (San Francisco, CA, USA) | Guerciolini R, Jadhav V, McSwiggen J, Vargeese C | 5/27/2005 | 5/26/2006 |
WO 2006126600 | A pharmaceutical composition for treating vascular occlusive disease, comprising a nucleic acid construct capable of inhibiting the expression of a midkine gene through RNA interference in the presence of the collagen molecule. | Cell Signals (Yokohama, Japan), National University Corp. of Nagoya University (Nagoya, Japan) | Banno H, Kadomatsu K, Komori K, Muramatsu T, Sakuma S, Takei Y | 5/25/2005 | 5/24/2006 |
WO 2006123800 | An RNA interference induction element for producing a short interfering RNA for a target gene, with a nucleotide sequence that has the nucleic acid of a DNA sequence with specified base pairs, continuous nucleotides or specified homology. | Japan Science and Technology Agency (Kawaguchi, Japan), Kurume University (Kurume, Japan) | Ishii K, Takahashi K | 5/18/2005 | 5/15/2006 |
WO 2006110813 | A composition comprising a nucleic acid agent capable of inhibiting the expression via RNA interference of gene that enhances unwanted neovascularization; useful for treating cancer, ocular diseases, arthritis or inflammatory diseases. | Intradigm (Rockville, MD, USA) | Lui Y, Scaria PV, Schiffelers R, Tang QQ, Woodle MC, Xie FY, Xu J, Yang Lu P, Zhou Q | 4/12/2005 | 4/12/2006 |
US 20060234973 | A method for inhibiting E2F1 polypeptide expression for treating, ameliorating or preventing inflammatory disorders, etc., comprising contacting the cell or tissue with an RNA interference reagent. | Fitzgerald K, Guo Q, Jackson DG | Fitzgerald K, Guo Q, Jackson DG | 4/14/2005 | 4/12/2006 |
WO 2006110688 | An RNA interference-inducing molecule targeted to a transcript of a respiratory virus; useful for preventing or treating viral infections, including human respiratory syncytial virus, rhinovirus and influenza infections. | Nastech Pharmaceutical (Bothell, WA, USA) | Ge Q, Kumar M, McSwiggen JA | 4/8/2005 | 4/7/2006 |
WO 2006105361 | A new nucleic acid for treating diseases associated with unwanted proliferation of cells (e.g., cancer) comprising a double-stranded nucleic acid that reduces ribonucleotide reductase subunit expression by RNA interference. | Calando Pharmaceuticals (Duarte, CA, USA) | Davis ME, Heidel JD, Rossi JJ | 3/31/2005 | 3/31/2006 |
US 20060241075 | A new short interfering RNA useful for studying, diagnosing and treating diseases that respond to the Desmoglein gene expression and/or activity (e.g., alopecia or dermatological disease). | Sirna Therapeutics (San Francisco, CA, USA) | McSwiggen J | 5/18/2001 | 10/26/2005 |
US 20060264396 | A composition useful in the treatment or prevention of endometrial cancer, comprising a nucleic acid molecule inducing RNA interference against human syndecan-1 gene expression, and a carrier. | Ajou University Industry Cooperation Foundation (Suwon, Korea) | Choi DS, Min CK | 5/18/2005 | 8/22/2005 |
