Table 1 Recent patent applications in gene expression
Patent number | Description | Assignee | Inventor | Priority application date | Publication date |
|---|---|---|---|---|---|
US 20090013433 | A transgenic plant comprising a brassinosteroid receptor BRI1 kinase inhibitor 1 (BKI1)-type polypeptide or modulator of bki1-type gene expression; useful for displaying modulated brassinosteroid response and plant phenotype. The modulator in the transgenic plant is an RNA interference or antisense molecule that inhibits translation of an mRNA that encodes a BKI1-type polypeptide. | Salk Institute for Biological Sciences (La Jolla, CA, USA) | Chory J, Wang X | 1/10/2007 | 1/8/2009 |
WO 2009002440 | A nucleic acid molecule that downregulates expression of an epidermal growth factor receptor (EGFR) gene via RNA interference; useful for preparing a composition for treating or preventing EGFR-expressing cancer. | Liu Y, Xie FY, Yang X | Liu Y, Xie FY, Yang X | 6/22/2007 | 12/31/2008 |
WO 2008155918 | A method of promoting or inhibiting activity of hypoxia-inducible factor-1α (HIF-1α), involving increasing or reducing the interaction of intracellular inhibitor of factor inhibiting HIF-1 (iFIH) protein and factor inhibiting HIF-1 (FIH-1) protein, or increasing or reducing the interaction of intracellular membrane type 1–matrix metalloproteinase–cytoplasmic tail binding protein (MT1-MMP-CP) and FIH-1 protein. The interaction of iFIH-1 and FIH-1 protein is reduced by decreasing the expression of iFIH-1 protein by RNA interference. | University of Tokyo (Tokyo) | Sakamoto T, Seiki M | 6/20/2007 | 12/24/2008 |
US 20080311081, WO 2008156702, WO 2008156661 | An invasive bacterium comprising small interfering RNA that interferes with the mRNA of human papilloma virus (HPV) oncogenes; useful for treating or preventing a viral disease or disorder—e.g., HPV infection. | Cequent Pharmaceuticals (Cambridge, MA, USA); Fruehauf J, Laroux FS, Sauer NJ, Vaze MB, Beth Israel Deaconess Medical Center (Boston) | Fruehauf J, Laroux FS, Sauer NJ, Vaze MB, Li C | 6/15/2007 | 12/18/2008, 12/24/2008, 12/24/2008 |
WO 2008152131 | A new RNA interference agent comprising sense strand; useful for treating a human subject afflicted with cystic fibrosis or Liddle syndrome, and for treating and/or preventing hypertension and/or renal insufficiency in a human subject. | Novartis (Basel, Switzerland) | Danahay HL, Geick A, Hickman E, Tan P, van Heeke G, Vornlocher H | 6/15/2007 | 12/18/2008 |
JP 2008301812 | A kit comprising a vector containing a promoter derived from phage used for producing double-stranded RNA having an RNA interference effect in lactic acid bacteria. The lactic acid bacteria are useful in compositions for killing intestinal parasites and treating enteric diseases—e.g., Caenorhabditis and Ascaris. | Okayama University (Japan) | Otsuki T, Shishido M | 5/10/2007 | 12/18/2008 |
WO 2008148304, CN 101314775 | An HIV-targeted RNA interference target sequence; useful for treating HIV infection. | Xiamen University (Xiamen, China); Yang Sheng Tang Co. (Haikou, China) | Cheng T, Miao J, Xia N, Zhang J, Zhang T, Zhang Y | 5/31/2007 | 12/11/2008, 12/3/2008 |
CN 101246169 | A diagnostic reagent for oral squamous cell carcinoma comprising a reagent capable of detecting the expression level of RACK1 protein and its mRNA content; useful for preparing a kit or biochip for oral mucosa carcinoma. The drug comprises an RNA interference molecule of RACK1 protein. | University of Sichuan (China) | Ceng X, Chen Q, Huang C, Wang Z | 5/23/2007 | 8/20/2008 |
JP 2008167739 | A novel modified double-stranded RNA having RNA interference activity, comprising sense strand RNA having a complementary base sequence to a target gene and an antisense strand RNA for suppressing expression of the target gene. | National Institute of Advanced Industrial Science and Technology (Tokyo) | Bakalova R, Kubo T, Oba H, Zhelev Z | 6/14/2006 | 7/24/2008 |
