Table 1 Recent patent applications in high-throughput drug screening
From: Recent patent applications in high-throughput drug screening
Patent number | Description | Assignee | Inventor | Priority application date | Publication date |
|---|---|---|---|---|---|
US 20100056390 | A three-dimensional cell culture system comprising a cell of interest and a natural or synthetic hydrogel incorporating the cell of interest; useful in an apparatus for high-throughput drug screening. | Fischbach C | Fischbach C | 7/29/2008 | 3/4/2010 |
US 20100041901 | A new fluorescent compound having a central linker element linking two 6,5-ring systems or two 6,6,5-ring systems; useful as a fluorescent reporter molecule in a biological assay for drug discovery and as a fluorescent marker for protein identification. | Cairns N | Cairns N | 8/14/2008 | 2/18/2010 |
WO 2010019388, US 20100041046 | A method of discretizing and manipulating sample volumes to perform a digital polymerase chain reaction, comprising providing a fluidic lattice with a flow channel and many fluidic harbors. | University of Washington (Seattle) | Chiu DT, Cohen DE, Cohen DW, Jeffries GDM | 8/15/2008 | 2/18/2010, 2/18/2010 |
US 7659322 | A method of forming polyanhydride for controlled drug delivery involving irradiating diacid with microwave radiation in the presence of carboxylic anhydride to acylate the diacid to form a prepolymer, and irradiating the prepolymer with microwave radiation to polymerize and yield the polyanhydride. | Iowa State University Research Foundation (Ames, IA, USA) | Mallapragada SK, Vogel BM | 12/16/2004 | 2/9/2010 |
US 20100028892 | A reporter gene system comprising an exogenous protease with or without an exogenous activator of protease, which cleaves transcription factor protein; useful for monitoring protease activity in living yeast, e.g., Saccharomyces cerevisiae. | Burnham Institute for Medical Research (La Jolla, CA, USA) | Cuddy M, Hayashi H, Reed JC | 7/16/2008 | 2/4/2010 |
WO 2010011939, US 20100022416 | An etched plate comprising a substrate, a first layer partially disposed on the substrate and etched features; useful for measuring electrode-induced property in an etched features assay array having >5,000 etched features. | Life BioScience (Albuquerque, NM, USA) | Buckley CT, Flemming JH, Ridgeway B | 7/25/2008 | 1/28/2010, 1/28/2010 |
WO 2010008519 | A marker comprising a binding agent, e.g., biotin, and a chromophore, e.g., fluorescein; useful for investigating analytes in vitro and for anatomic, physiologic and biochemical parameters. | Hu H, Li S, Metters A, Wang Q | Hu H, Li S, Metters A, Wang Q | 7/14/2008 | 1/21/2010 |
WO 2010003908 | A biological system for analyses of the inhibitory mode of action exerted by a compound on the ubiquitin proteasome system for cellular protein degradation, comprising expression of heterologous fusion proteins in a eukaryotic host cell. | Esmaeilzadeh S, Jakobsson A, Pouya A | Beskow A, Bjoerk Grimberg K, Bott LC, Dantuma N, Salomons F, Young P | 7/8/2008 | 1/14/2010 |
US 20090246802, WO 2009124135 | A new annexin derivative comprising amino acids conjugated to a polarity-sensitive fluorophore; useful for detecting apoptosis and for monitoring cell health. | University of Southern California (Los Angeles) | Langen R | 4/1/2008 | 10/1/2009, 10/8/2009 |
WO 2009047760 | A new apparatus for measuring protein translation, comprising a cell or subcellular compartment where the cell or subcellular compartment comprises at least one protein synthesis element. | Anima Cell Metrology (Bernardsville, NJ, USA) | Smilansky Z | 10/9/2007 | 4/16/2009 |
