Combinatorial chemistry has evolved from its early focus as a random strategy for generating molecular diversity into a powerful design technology for developing and optimizing drug candidates.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Buy this article
- Purchase on SpringerLink
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Commercial Opportunities in Combinatorial Chemistry, p. 14. 1995. Bioinformation Associates, Boston, MA.
Geysen, H.M., Meloen, R.H., and Barteling, S.J. 1984 Proc. Natl. Aead. Scl. USA 81: 3998.
Furka, A., et al. 1991 Int. J. Pept. Protein Res. 37: 487.
Houghton, R.A. 1985 Proc. Natl. Acad, Scl. USA 82: 5131.
Rutenbur, E., McPhee, R., Kaplan, A.P., Gallion, Hogan, J.C., Craik, C.S., and Stroud, R.M. 1985 Proc. Natl. Acad. Sci. USA 82: 1545.
Baldino, C.M., Casebier, D.S., Caserta, J., Slobodkin, G., Tu, C., and Coffen, D.L. Convergent parallel synthesis. Syn. Lett. In press.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Hogan, J. Combinatorial chemistry in drug discovery. Nat Biotechnol 15, 328–330 (1997). https://doi.org/10.1038/nbt0497-328
Issue date:
DOI: https://doi.org/10.1038/nbt0497-328
This article is cited by
-
Impact of Micellar Surfactant on Supersaturation and Insight into Solubilization Mechanisms in Supersaturated Solutions of Atazanavir
Pharmaceutical Research (2017)
-
Diagnosing the decline in pharmaceutical R&D efficiency
Nature Reviews Drug Discovery (2012)
