Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Commentary
  • Published:

Next-generation biomarkers for detecting kidney toxicity

Nature Biotechnology volume 28, pages 436–440 (2010)Cite this article

Subjects

There is a paucity of biomarkers that reliably detect nephrotoxicity. The Predictive Safety Testing Consortium (PSTC) faced several challenges in identifying novel safety biomarkers in the renal setting.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

  • Purchase on SpringerLink
  • Instant access to the full article PDF.

USD 39.95

Prices may be subject to local taxes which are calculated during checkout

Figure 1: The utility of biomarkers to detect injury to specific nephron segments affected by various nephrotoxicants.

References

  1. Mehta, R.L. et al. Kidney Int. 66, 1613–1621 (2004).

    Article  Google Scholar 

  2. Blowey, D.L. Adolesc. Med. Clin. 16, 31–43 (2005).

    Article  Google Scholar 

  3. Mutlib, A.E. et al. Toxicol. Appl. Pharmacol. 169, 102–113 (2000).

    Article  CAS  Google Scholar 

  4. Perazella, M.A. Clin. J. Am. Soc. Nephrol. 4, 1275–1283 (2009).

    Article  CAS  Google Scholar 

  5. Kellum, J.A., Levin, N., Bouman, C. & Lameire, N. Curr. Opin. Crit. Care 8, 509–514 (2002).

    Article  Google Scholar 

  6. Vaidya, V.S. et al. Nat. Biotechnol. 28, 478–485 (2010).

    Article  CAS  Google Scholar 

  7. Wingard, J.R. et al. Clin. Infect. Dis. 29, 1402–1407 (1999).

    Article  CAS  Google Scholar 

  8. Molitoris, B.A. et al. J. Am. Soc. Nephrol. 18, 1992–1994 (2007).

    Article  CAS  Google Scholar 

  9. Chertow, G.M., Burdick, E., Honour, M., Bonventre, J.V. & Bates, D.W. J. Am. Soc. Nephrol. 16, 3365–3370 (2005).

    Article  Google Scholar 

  10. Waikar, S.S. & Bonventre, J.V. J. Am. Soc. Nephrol. 20, 672–679 (2009).

    Article  CAS  Google Scholar 

  11. Dieterle, F. et al. Nat. Biotechnol. 28, 455–462 (2010).

    Article  CAS  Google Scholar 

  12. Vaidya, V.S., Ferguson, M.A. & Bonventre, J.V. Annu. Rev. Pharmacol. Toxicol. 48, 463–493 (2008).

    Article  CAS  Google Scholar 

  13. Ferguson, M.A., Vaidya, V.S. & Bonventre, J.V. Toxicology 245, 182–193 (2008).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Joseph V. Bonventre and Vishal S. Vaidya are in the Renal Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA;,

    Joseph V Bonventre & Vishal S Vaidya

  2. Robert Schmouder is in Translational Sciences, Novartis Institutes for BioMedical Research, East Hanover, New Jersey, USA;,

    Robert Schmouder

  3. Peter Feig is in Cardiovascular Clinical Research, Merck Research Laboratories, Rahway, New Jersey, USA;,

    Peter Feig

  4. Frank Dieterle is in Translational Sciences, Novartis Institutes for BioMedical Research, Basel, Switzerland.,

    Frank Dieterle

Authors
  1. Joseph V Bonventre
    View author publications

    Search author on:PubMed Google Scholar

  2. Vishal S Vaidya
    View author publications

    Search author on:PubMed Google Scholar

  3. Robert Schmouder
    View author publications

    Search author on:PubMed Google Scholar

  4. Peter Feig
    View author publications

    Search author on:PubMed Google Scholar

  5. Frank Dieterle
    View author publications

    Search author on:PubMed Google Scholar

Corresponding author

Correspondence to Joseph V Bonventre.

Ethics declarations

Competing interests

R.S. and F.D. are employees of Novartis and P.F. is an employee of Merck.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Bonventre, J., Vaidya, V., Schmouder, R. et al. Next-generation biomarkers for detecting kidney toxicity. Nat Biotechnol 28, 436–440 (2010). https://doi.org/10.1038/nbt0510-436

Download citation

  • Issue date:

  • DOI: https://doi.org/10.1038/nbt0510-436

This article is cited by

Search

Advanced search

Quick links

Nature Briefing: Translational Research

Sign up for the Nature Briefing: Translational Research newsletter — top stories in biotechnology, drug discovery and pharma.

Get what matters in translational research, free to your inbox weekly. Sign up for Nature Briefing: Translational Research