This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Buy this article
- Purchase on SpringerLink
- Instant access to the full article PDF.
USD 39.95
Prices may be subject to local taxes which are calculated during checkout
References
Galloway, J.A. and Root, M.A. 1972. New forms of insulin. Diabetes 21:(supp. 2)637.
Touitou, E., Donbrow, M. and Rubenstein, A. 1978. Effective intestinal absorption of insulin in diabetic rats using a new formula tion approach. J. Pharmacol. 32: 108.
Nishihata, T., Rytting, J.H., Kamada, A. and Higuchi, T. 1981. Enhanced intestinal absorption of insulin in the presence of sodium 5-methoxysalicylate. Diabetes 30: 1065.
Camilleri, M., Colemont, L.J., Phillips, S.F., Brown, M.L., Thomforde, G.M., Chapman, N. and Zinsmeister, A.R. 1989. Human gastric emptying and colonic filling of solids characterized by a new method. A. J. Physio. 257(Gastrointest. Liver Physiol. 20):G284.
Touitou, E. and Rubenstein, A. 1986. Tar geted enteral delivery of insulin to rats. Int'l. J. Pharmacuetics 30: 95.
Peppercorn, M.A. and Goldman, P. 1972. The role of intestinal bacteria in the metab olism of salicylazosulfapyridine. J. Pharmacol. Exper. Therap. 181: 555.
Kumar, G.S., Savariar, C., Saffran, M. and Neckers, D.C. 1985. Chelating copolymers containing photosensitive functionalities. 3. Photochromism of cross-linked polymers. Macromolecules 18: 1525.
Saffran, M. and Neckers, D.C. 1987. Meth od of use of polymers containing cross-linked azo bonds for releasing therapeutic agents into the lower gastrointestinal tract. U.S. Patent 4,663,308.
Saffran, M., Kumar, G.S., Savariar, C., Burnham, J.C., Williams, F. and Neckers, D.C. 1986. A new approach to the oral administration of insulin and other peptide drugs. Science 233: 1081.
Saffran, M., Field, J.B., Pena, J., Jones, R.H. and Okuda, Y. 1990. Oral insulin in diabetic dogs. Proc. Ann. Mtg. of the Am. Diabetic Assn., Detroit, June 1–9, 81 (abstract).
Saffran, M., Field, J.B., Pena, J., Jones, R.H. and Okuda, Y. (1990). In prep.
Teng, L.L. 1986. Orally administered biologically active peptides and proteins. U.S. Patent 4,582,820.
Patel, H.M. and Ryman, B.E. 1976. Oral administration of insulin by encapsulation within liposomes. FEBS Lett. 62: 60.
Kidron, M., Bar-On, H., Berry, E.M. and Ziv, E. 1982. The absorption of insulin from various regions of the rat intestine. Life Sciences 31: 2837.
Gardner, M.L.G. 1988. Gastrointestinal absorption of intact proteins. Ann. Rev. Nutr. 8: 329.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Saffran, M. Delivering Protein Drugs Orally. Nat Biotechnol 8, 574–575 (1990). https://doi.org/10.1038/nbt0690-574
Issue date:
DOI: https://doi.org/10.1038/nbt0690-574