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Emerging themes in medicinal glycoscience

Nature Biotechnology volume 18, pages 835–841 (2000)Cite this article

Abstract

The recognition of complex carbohydrates and glycoconjugates as mediators of important biological processes has stimulated investigation into their therapeutic potential. New approaches for the simplification of glycoconjugate synthesis are overcoming the limitations of existing methods and providing a diverse array of these biomolecules. As the accessibility of glycoconjugates increases, carbohydrate-based constructs are becoming available for analysis as medicinal agents in a wide range of therapies.

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Figure 1: Selected approaches for the synthesis of complex glycoconjugates.
Figure 2: Strategies for the inhibition of influenza virus.
Figure 3: The biosynthesis of bacterial cell wall peptidoglycan involves both transglycosylase and transpeptidase activity.
Figure 4: Aminoglycosides exert their antibiotic effects through binding of the bacterial 16S rRNA A-site.
Figure 5
Figure 6

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  1. Department of Chemistry, The Scripps Research Institute and Skaggs Institute for Chemical Biology, 10550 North Torrey Pines Road, La Jolla, 92037, CA

    Kathryn M. Koeller & Chi-Huey Wong

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Koeller, K., Wong, CH. Emerging themes in medicinal glycoscience. Nat Biotechnol 18, 835–841 (2000). https://doi.org/10.1038/78435

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