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Clear vision for a structure-seeking business

Nature Biotechnology volume 18, page 1017 (2000)Cite this article

I read with interest the editorial on structural genomics in the September issue of Nature Biotechnology and decided, as CEO of Structural GenomiX (San Diego, CA)—one such “smart, agile, and fast” startup in this area—that it was worthwhile setting out my views on the business of structure determination.

X-ray structure resolution is undergoing the same revolution that DNA sequencing underwent several years ago. The linearity of the previous approach to structure determination is being replaced by massively parallel systems for cloning, expression, protein purification, and protein crystallization. Dedicated X-ray diffraction beam lines suitable for very high-throughput multiwavelength anomalous diffraction (MAD) phasing experiments, such as the beam line Structural GenomiX is building at the Advanced Photon Source of the US Department of Energy's Argonne National Laboratory (Chicago, IL), are being constructed, or existing beam lines are being adapted toward that end.

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References

  1. Fraser, C.M. et al. Nature 406, 799–803 (2000).

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  1. president and CEO of Structural GenomiX, 10505 Roselle Street, San Diego, 92121, CA

    Tim Harris

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  1. Tim Harris
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Harris, T. Clear vision for a structure-seeking business. Nat Biotechnol 18, 1017 (2000). https://doi.org/10.1038/80119

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