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Reply to 'Glycoprotein sialylation in plants?'

Nature Biotechnology volume 22, pages 1352–1353 (2004)Cite this article

Shah et al. reply:

The ability to sialylate proteins is a critical attribute for plant expression systems if they are to realize their potential as bioreactors for engineered human protein therapeutics. Contrary to accepted dogma, our report demonstrated the presence of sialic acids and sialoglycoconjugates in plants. We regret that Faye and colleagues' efforts to reproduce our experiments resulted in observations and conclusions we view to be erroneous, but welcome the opportunity to respond and are pleased to share the knowledge and experience we have gained in investigating glycosylation in plants to help our colleagues overcome conceptual and technical constraints. We contend that Faye and colleagues have misunderstood the following salient points.

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Reply to 'Glycoprotein sialylation in plants?'. Nat Biotechnol 22, 1352–1353 (2004). https://doi.org/10.1038/nbt1104-1352

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