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Systems biology and the host response to viral infection

Nature Biotechnology volume 25, pages 1383–1389 (2007)Cite this article

Will our increasing understanding of virus-host interactions translate into a new generation of antiviral therapeutics or steer us toward an expensive journey to nowhere?

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Figure 1
Figure 2: Example highlighting the distinct mechanisms of antiviral actions by pharmacological inhibitors of cellular cyclin-dependent kinases (CDKs) compared to conventional antiviral drugs.
Figure 3: Functional relationships of activated of cell death responses during r1918 influenza virus infection.

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Author information

Authors and Affiliations

  1. Seng-Lai Tan is in the Department of Hematology and Oncology Research, Amgen Inc., 1201 Amgen Court West, AW1-J4144, Seattle, Washington 98119, USA.,

    Seng-Lai Tan

  2. Gopinath Ganji is at the Lilly Singapore Centre for Drug Discovery, 1 Science Park Road no. 04-01, The Capricorn, Singapore Science Park II, Singapore 117528.,

    Gopinath Ganji

  3. Sean Proll and Michael G. Katze are in the Department of Microbiology, Bryan Paeper, University of Washington, 960 Republican Street, Seattle, Washington 98109, USA. honey@u.washington.edu,

    Bryan Paeper, Sean Proll & Michael G Katze

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  5. Michael G Katze
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Tan, SL., Ganji, G., Paeper, B. et al. Systems biology and the host response to viral infection. Nat Biotechnol 25, 1383–1389 (2007). https://doi.org/10.1038/nbt1207-1383

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