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Lectins sweet-talk proteins into ERAD

Nature Cell Biology volume 10, pages 251–253 (2008)Cite this article

How cells decide that a protein is misfolded is a mystery. The endoplasmic reticulum integrates N-linked glycosylation into the decision as to whether a protein is misfolded. The basic strategy of glycan-based recognition, previously identified in yeast, is conserved in mammals but is expanded, possibly to accommodate a more complex client portfolio.

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Figure 1: ER-associated degradation via the Hrd1 complex.

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Authors and Affiliations

  1. Songyu Wang and Davis Ng are in the Temasek Life Sciences Laboratory and the Department of Biological Sciences, National University of Singapore, 117604 Singapore. davis@tll.org.sg,

    Songyu Wang & Davis T. W. Ng

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  1. Songyu Wang
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  2. Davis T. W. Ng
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Wang, S., Ng, D. Lectins sweet-talk proteins into ERAD. Nat Cell Biol 10, 251–253 (2008). https://doi.org/10.1038/ncb0308-251

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