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The Goldilocks tale of cytokines: Getting it right

Nature Cell Biology volume 3, page E143 (2001)Cite this article

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Novel Cytokine Inhibitors

Edited by:
  • G. Higgs &
  • B. Henderson
Birkhauser · October 2000 Hardback £92/$140

This latest volume in the Progress in Inflammation Research series edited by Higgs and Henderson comes at a time when the therapeutic potential of anti-cytokine drugs are being realized in spectacular fashion. Recombinant protein therapies utilizing two different approaches to inhibiting tumour necrosis factor (TNF) activity, soluble TNF-receptor fusions and anti-TNF monoclonal antibodies, are approved for use in rheumatoid arthritis and inflammatory bowel disease, chronic inflammatory conditions with a wealth of data implicating TNF in disease pathogenesis. The efficacy of these biological drugs seems to exceed or equal anything else in the current armamentarium, combining disease-modifying activity with rapid onset of action. Testimonies of patients and their physicians border on the miraculous. Clinical trials of inhibitors of interleukin-1 (IL-1), IL-4, IL-5, IL-6 and IL-8 are underway for various diseases presumed to be cytokine-driven.

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  1. the Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, PO Box 19024, Seattle, 98109, Washington, USA

    David Hockenberry

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  1. David Hockenberry
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Hockenberry, D. The Goldilocks tale of cytokines: Getting it right. Nat Cell Biol 3, E143 (2001). https://doi.org/10.1038/35078609

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