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Meddling with methylation

Covalent modification of DNA by methylation is crucial for maintaining the stability and structure of chromatin. Reports of the effects that altered methylation has for cancer development stress the importance of balanced genomic methylation.

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Figure 1: Changes in the patterns of DNA methylation on different DNA elements contribute to the genesis of altered chromosomes in cancer.

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Hsieh, CL., Jones, P. Meddling with methylation. Nat Cell Biol 5, 502–503 (2003). https://doi.org/10.1038/ncb0603-502

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