The ATM and ATR protein kinases are important mediators of the cellular response to DNA damage. They regulate multiple cellular functions as part of a stress response programme, including the activation of cell-cycle checkpoints, DNA replication, DNA repair and DNA recombination. A provocative new study suggests that ATM and ATR also regulate normal DNA replication in unperturbed cells.
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Fisher, D., Méchali, M. Sleeping policemen for DNA replication?. Nat Cell Biol 6, 576–577 (2004). https://doi.org/10.1038/ncb0704-576
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DOI: https://doi.org/10.1038/ncb0704-576
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