Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Knocking signalling out of the dystrophin complex

Abstract

Mice lacking dystrobrevin, a dystrophin-associated protein, exhibit a new form of muscular dystrophy in which the integrity of muscle fibres is maintained, but a component of muscle-cell signalling is disrupted.

This is a preview of subscription content, access via your institution

Access options

Buy this article

USD 39.95

Prices may be subject to local taxes which are calculated during checkout

Figure 1: The dystrophin glycoprotein complex.

References

  1. Monaco, A. P. et al. Nature 323, 646–650 (1986).

    Article  CAS  Google Scholar 

  2. Lim, L. E. & Campbell, K. P. Curr. Opin. Neurol. 11, 443–452 (1998).

    Article  CAS  Google Scholar 

  3. Peters, M. F. et al. J. Cell Biol. 142, 1269–1278 (1998).

    Article  CAS  Google Scholar 

  4. Grady, R. M. et al. Nature Cell Biol. 1, 215–220 (1999).

    Article  CAS  Google Scholar 

  5. Helbling-Leclerc, A. et al. Nature Genet. 11, 216–218 (1995).

    Article  CAS  Google Scholar 

  6. Brenman, J. E., Chao, D. S., Xia, H., Aldape, K. & Bredt, D. S. Cell 82, 743–752 (1995).

    Article  CAS  Google Scholar 

  7. Thomas, G. D. et al. Proc. Natl Acad. Sci. USA 95, 15090–15095 (1998).

  8. Brenman, J. E. et al. Cell 84, 757–767 (1996).

    Article  CAS  Google Scholar 

  9. Ahn, A. H. & Kunkel, L. M. J. Cell Biol. 128, 363–371 (1995).

    Article  CAS  Google Scholar 

  10. Schultz, J. et al. Nature Struct. Biol. 5, 19–24 (1998).

    Article  CAS  Google Scholar 

  11. Hillier, B. J. et al. Science 284, 812–815 (1999).

    Article  CAS  Google Scholar 

  12. Roberts, R. G. et al. Nature Genet. 13, 223–226 (1996).

    Article  CAS  Google Scholar 

  13. Peters, M. F. et al. J. Biol. Chem. 272, 31561–31569 (1997).

    Article  CAS  Google Scholar 

  14. Sadoulet-Puccio, H. M., Rajala, M. & Kunkel, L. M. Proc. Natl Acad. Sci. USA 94, 12413–12418 (1997).

    Article  CAS  Google Scholar 

  15. Chao, D. S. et al. J. Exp. Med. 184, 609–618 (1996).

    Article  CAS  Google Scholar 

  16. Metzinger, L. et al. Hum. Mol. Genet. 6, 1185–1191 (1997).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to David S. Bredt.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Bredt, D. Knocking signalling out of the dystrophin complex. Nat Cell Biol 1, E89–E91 (1999). https://doi.org/10.1038/12085

Download citation

  • Issue date:

  • DOI: https://doi.org/10.1038/12085

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing