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eIF4A goes beyond translation

Nature Cell Biology volume 8, pages 1319–1321 (2006)Cite this article

A new study has revealed an unexpected role for eukaryotic translation initiation factor 4A (eIF4A) in suppressing Decapentaplegic (Dpp) signalling. On activation of Dpp signalling, eIF4A promotes degradation of the downstream signalling components Mad and Medea in a translation-independent manner.

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Figure 1: Schematic representation of Dpp signalling in Drosophila.

References

  1. Li, J. & Li, W.X. Nature Cell Biol. 8, 1407–1414 (2005).

    Article  Google Scholar 

  2. Li, W.X. & Gelbart, W.M. Genetics 171, 1629–1641 (2005).

    Article  CAS  Google Scholar 

  3. Raftery, L.A., Twombly, V., Wharton, K. & Gelbart, W.M. Genetics 139, 241–254 (1995).

    CAS  PubMed  PubMed Central  Google Scholar 

  4. Izzi, L. & Attisano, L. Oncogene 23, 2071–2078 (2004).

    Article  CAS  Google Scholar 

  5. Podos, S.D., Hanson, K.H., Wang, Y.-C. & Ferguson, E.L. Dev. Cell 1, 567–578 (2001).

    Article  CAS  Google Scholar 

  6. Liang, Y.-Y. et al. J. Biol. Chem. 278, 26307–26310 (2003).

    Article  CAS  Google Scholar 

  7. Massague, J., Seoane, J. & Wotton, D. Genes Dev. 19, 2783–2810 (2005).

    Article  CAS  Google Scholar 

  8. Hernandez, G. & Vazquez-Piazola, P. Mech. Dev. 122, 865–876 (2005).

    Article  CAS  Google Scholar 

  9. Chen, H.B., Shen, J.S., Ip, T. & Xu, L. Genes Dev. 20, 648–653 (2006).

    Article  CAS  Google Scholar 

  10. Knockaert, M., Sapkota, G., Alarcon, C., Massage, J. & Brivanlou, A.H. Proc. Natl Acad. Sci. USA 103, 11940–11945 (2006).

    Article  CAS  Google Scholar 

  11. Niessing, D., Blanke, S. & Jäckle, H. Genes Dev. 16, 2576–2582 (2002).

    Article  CAS  Google Scholar 

  12. Parker, L., Stathakis, D.G. & Arora, K. Prog. Mol. Subcell. Biol. 34, 73–101 (2004).

    Article  CAS  Google Scholar 

  13. Tsuneizumi, K. et al. Nature 389, 627–631 (1997).

    Article  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. University of Basel, Klingelbergstrasse 70, Basel, 4056, Switzerland

    Markus Affolter & George Pyrowolakis

  2. Institute of Biology I, University of Freiburg, Hauptstrasse 1, Freiburg, 79104, Germany

    Markus Affolter & George Pyrowolakis

Authors
  1. Markus Affolter
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  2. George Pyrowolakis
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Affolter, M., Pyrowolakis, G. eIF4A goes beyond translation. Nat Cell Biol 8, 1319–1321 (2006). https://doi.org/10.1038/ncb1206-1319

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