Supplementary Figure 7: G6PD levels are associated with breast cancer metastasis and a role for G6PD and TAp73 in tumor growth.
From: TAp73 enhances the pentose phosphate pathway and supports cell proliferation
(a,b) G6PD levels are associated with breast cancer metastasis. (a) Cox multivariable regression for metastasis risk using the indicated variables was performed on a cohort of 871 breast cancer patients. Shown are the hazard ratio (HR) and p-values. (b) Kaplan-Meier survival curves for metastasis-free survival. The patients were stratified by mean G6PD levels (‘hi’ is greater than mean, ‘lo’ is less than or equal to mean). P-value was determined by the log-rank test. (c) Representative images of animals three weeks after injected with TAp73+/+ and TAp73−/− MEF cells stably overexpressing G6PD or vector control. (d) Mice were injected with TAp73+/+ and TAp73−/− MEF cells that were treated with control or G6pd siRNA, and were fed with water containing no NAC or 40 mM NAC. Representative images of animals at three weeks are shown.
