Supplementary Figure 1: Requirement of TAp73 for cell proliferation and tumor growth.
From: TAp73 enhances the pentose phosphate pathway and supports cell proliferation
(a) Schematic representation of p53 and the TAp73 and ΔNp73 isoform classes. Each p73 isoform class comprises various splicing variants (α, β, γ etc.) that differ in their C-terminal regions. TA: transactivation domain. DBD: DNA-binding domain. OD: oligomerization domain. SAM: sterile alpha motif. (b) TAp73+/+ and TAp73−/− MEF cells cultured for 4 days were stained with crystal violet. (c) Representative images of animals two weeks after injected with TAp73+/+ and TAp73−/− MEF cells. (d) U2OS cells stably expressing control or TAp73 shRNA were stained with crystal violet at day 6. (e,f) Proliferation of two independent clones of ΔNp73−/− and ΔNp73+/+ MEFs in culture and images of crystal violet staining at day 6. Data are means ± SD (n = 3 independent experiments).
