Supplementary Figure 4: Targeted neuronal expression of dNK rescues mitochondrial dysfunction in pink1 mutants. | Nature Cell Biology

Supplementary Figure 4: Targeted neuronal expression of dNK rescues mitochondrial dysfunction in pink1 mutants.

From: Enhancing nucleotide metabolism protects against mitochondrial dysfunction and neurodegeneration in a PINK1 model of Parkinson’s disease

Supplementary Figure 4

(a) Enhanced expression of components of both the de novo and salvage nucleotide synthesis pathways in adult heads of pink1 mutant flies. Data are shown as the mean±SEM (n values are indicated in the bars, asterisks, two-tailed unpaired t test). See Supplementary Table 9 for statistics source data. (b) Enhanced respiration in the heads of elav>dNK flies. Data are shown as the mean±SEM (n values are indicated, asterisks, two-tailed unpaired t test). (c) Neuronal expression of dNK enhances ATP levels. Data are shown as the mean±SEM (n = 6 per sample, asterisks, two-tailed unpaired t test). (d) Neuronal expression of dNK enhanced locomotor activity. Data are shown as the mean±SEM (n values are indicated, asterisks, two-tailed unpaired t test). (e) Neuronal expression of dNK enhanced climbing ability (mean±SEM, n = 100 flies per genotype, asterisks, two-tailed unpaired t test). See also Supplementary Fig. 4.

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