Supplementary Figure 5: α-catenin negatively correlates with NF-κB signaling components in human breast tumors. | Nature Cell Biology

Supplementary Figure 5: α-catenin negatively correlates with NF-κB signaling components in human breast tumors.

From: α-catenin acts as a tumour suppressor in E-cadherin-negative basal-like breast cancer by inhibiting NF-κB signalling

Supplementary Figure 5

(a) Box plots comparing CTNNA1 expression in normal breast tissues and in luminal A, luminal B and HER2+ breast tumors (n = 32, 13 and 4 patient samples, respectively). Statistical significance was determined by the Wilcoxon test. The boxes show the median and the interquartile range. The whiskers show the minimum and maximum. (b) Kaplan-Meier curves of relapse-free survival times of total breast cancer patients and patients with luminal A, luminal B or HER2+ breast cancer (n = 1370, 869 and 161 patient samples, respectively), stratified by CTNNA1expression levels. Statistical significance was determined by the log-rank test. (c) Scatterplots showing the inverse correlation of CTNNA1 with TNF (left panel) or RELB (right panel) expression in human breast tumors, based on the microarray data from TCGA. Statistical significance was determined by Spearman rank correlation test. Rs= Spearman rank correlation coefficient.

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