Emerging data support that RNA methylation plays important roles in RNA processing and metabolism. The methyltransferases Mettl3 and Mettl14 are shown to catalyse N6-methyladenosine (m6A) RNA modification in embryonic stem cells (ESCs). This m6A modification controls RNA metabolism and functions to destabilize mRNAs encoding developmental regulators to help sustain ESC self-renewal.
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Lin, S., Gregory, R. Methyltransferases modulate RNA stability in embryonic stem cells. Nat Cell Biol 16, 129–131 (2014). https://doi.org/10.1038/ncb2914
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DOI: https://doi.org/10.1038/ncb2914
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