Supplementary Figure 2: Gene set enrichment analyses (GSEA) of the CCM downregulated gene set and phosphorylated p38 MAPK levels in liver metastatic lesions formed by LiM2 cells. | Nature Cell Biology

Supplementary Figure 2: Gene set enrichment analyses (GSEA) of the CCM downregulated gene set and phosphorylated p38 MAPK levels in liver metastatic lesions formed by LiM2 cells.

From: Colon cancer cells colonize the lung from established liver metastases through p38 MAPK signalling and PTHLH

Supplementary Figure 2

(a) GSEA analysis of the CCM downregulated gene set in human colon cancer dataset (pooled GSE17537 and GSE14333 expression set). NES-normalized enrichment score; FDR-false discovery rate. (b) SW620 parental and LiM2 cells were injected intraliver and 40 days later mice were sacrificed. Size matched liver lesions were selected for immunohistochemistry staining with anti- phospho-p38 (P-p38) antibodies. Scale bar, 500 μm; inset scale bar, 50 μm; H-healthy tissue; T-tumour.

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