Supplementary Figure 7: N-cadherin expression in GFAP cells at different time-points after AraC treatment.
From: MT5-MMP regulates adult neural stem cell functional quiescence through the cleavage of N-cadherin
(a) Immunofluorescent detection of N-cadherin (green) and GFAP (red) in coronal sections from saline or AraC treated mice. The SEZ is delineated by two white dashed lines. (b) Higher magnification images of insets in (a). In saline controls, N-cadherin labels the membranes of the cells in the ependymal and subependymal areas (dashed lines). Immediately after the removal of the pumps (t = 0 h), the SEZ appears enriched in GFAP cells with high levels of N-cadherin (full arrowheads). Twelve and 24 h after the removal of the treatment, GFAP cells appear to downregulate N-cadherin (arrowheads). Scale bars: (a) 10 μm. (b) 5 μm.
