Supplementary Figure 7: Foxk1 loss increased the number and size of autophagic vacuoles.
From: Foxk proteins repress the initiation of starvation-induced atrophy and autophagy programs
Autophagic vacuoles (AV, white arrows) in control siNS knock-down cells are generally 500–600 nm in size and contain cytoplasmic materials such as mitochondria (black arrowheads), endoplasmic reticulum, and electron-dense ribosomes. Foxk1-depleted cells exhibit an increased number of multi-lamellar bodies (white arrowheads) and AVs. The AVs contain an abundance of degrading electron-dense ribosomes and membranes, which are likely to come from mitochondria and endoplasmic reticulum. Bar, 1 μm.
