Supplementary Figure 4: Genes coordinately up-regulated by Dex and TNF lie near up-regulated H3K27ac peaks. | Nature Cell Biology

Supplementary Figure 4: Genes coordinately up-regulated by Dex and TNF lie near up-regulated H3K27ac peaks.

From: Identification of nuclear hormone receptor pathways causing insulin resistance by transcriptional and epigenomic analysis

Supplementary Figure 4

(a) Venn diagram depicting genes induced by Dex and TNF. Of the 271 genes coordinately induced by both agents, 147 were flanked by at least one up-regulated H3K27ac peak within ±200 kb of the TSS. These 147 genes could be classified as associated with a ‘Dex-only’ peak (n = 22), a ‘TNF-only peak’ (n = 80), or both a Dex and a TNF-induced peak (n = 147). This last group could be further subcategorized into ‘Dex-TNF nonoverlapping’ peaks (n = 99) and ‘Dex-TNF overlapping’ peaks (n = 48). (b) Tracks from an up-regulated gene (Cebpd) showing a ‘Dex-only’ H3K27ac peak. (c) Tracks from an up-regulated gene (Igfbp3) showing a ‘TNF-only’ H3K27ac peak. (d) Tracks from an up-regulated gene (Ifngr1) showing a ‘Dex-TNF-nonoverlapping’ H3K27ac peak. (e) Tracks from an up-regulated gene (Fam46b) showing a ‘Dex-TNF-overlapping’ H3K27ac peak.

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