Supplementary Figure 3: MPC enhancers are enriched in TEAD motifs.
From: TEAD and YAP regulate the enhancer network of human embryonic pancreatic progenitors
(a) De novo motif search in MPC-selective enhancers revealed strong enrichment for TEAD recognition sequences, similarly to what we observed for the whole set of MPC enhancers. Other enriched matrices match binding sites of known pancreatic regulators. (b) TEAD motifs are highly enriched in enhancers bound by FOXA2 in both in vivo and in vitro MPCs, but not in enhancers bound by FOXA2 in adult pancreatic islets.
