Supplementary Figure 7: DNA binding motifs of Myc and E2f3 peaks associated with the 701 dysregulated genes in Rb KO villi.
From: Redeployment of Myc and E2f1–3 drives Rb-deficient cell cycles
Canonical DNA binding motifs (TTCCCGCC motif for E2f3, underlined with blue lines; CACGTG motif for Myc, underlined with reds lines) or strongest non-canonical motifs identified from peak sequences in indicated genomic regions of the 701 dysregulated gene in Rb KO villi. Data in this figure derived from pooled crypts (n = 32 mice for control, n = 27 mice for Rb KO) or villi of (n = 7 mice for control, n = 7 mice for Rb KO).
