Supplementary Figure 8: Expression of Wnt/β-catenin targets in Rb KO villi and auto-regulation of E2fs.
From: Redeployment of Myc and E2f1–3 drives Rb-deficient cell cycles
(a) Venn diagram showing the overlap between the 701 genes dysregulated in Rb KO villi and the 111 Wnt/β-catenin target genes. (b) ChIP-exo-seq tracks showing E2f3 binding to the E2f1 and E2f2 loci. The differential binding between control and Rb KO villi is highlighted in blue. Examples are derived from pooled villi (n = 7 mice for control, n = 7 mice for Rb KO). Scale bars in b represent 1kb.
