Supplementary Figure 10: OTUD3 expression is reduced in human breast cancer, which has no correlation with estrogen receptor, progesterone receptor or HER-2 expression.
From: Deubiquitylase OTUD3 regulates PTEN stability and suppresses tumorigenesis
a, Relative OTUD3 mRNA level in breast cancer tissues and matched normal control from 30 subjects. Data were analysed using Chi-square test. b–d, Whisker plots show the OTUD3 mRNA level in the cancer tissues classified into negative and positive groups based on estrogen receptor (b), progesterone receptor (c) or HER-2 (d) expression from 50 subjects. Data were analysed using Mann–Whitney test. e, Representative images from immunohistochemical staining of OTUD3, PTEN and p-Akt(S473) in three serial sections of the same tumor and matched adjacent tissue. The boxed areas in the left images were magnified on the right. A, adjacent tissue; C, carcinoma. Scale bar, 50 μm.
