Supplementary Figure 2: Topological analysis of the meta-adhesome interaction network.

(a) Clustered protein–protein interaction network model of the meta-adhesome. The largest connected graph component is displayed, comprising 11,430 interactions (black lines; edges) between 2,035 proteins (circles; nodes). Node size is proportional to degree and node colour is proportional to betweenness centrality. Black node borders indicate literature-curated adhesome⁴ components, which are labelled with gene names. (b) Betweenness centrality (a measure of the control a node exerts over the interactions of other nodes in the network) for each protein is plotted according to the number of datasets in which it was identified. Box-and-whisker plot shows the median (line), mean (plus sign), 25th and 75th percentiles (box) and 5th and 95th percentiles (whiskers) (n = 1,117, 518, 238, 102, 33, 25 and 10 mapped proteins identified in 1–7 datasets, respectively, with degree ≥1). ^∗P < 0.05, ^∗∗P < 0.01, ^∗∗∗P < 0.001; Kruskal–Wallis test with Dunn’s post hoc correction (see Supplementary Table 15 for statistics source data).