Supplementary Figure 1
From: Dicer1–miR-328–Bace1 signalling controls brown adipose tissue differentiation and function
(a) Relative expression of Cidea, Dio2, Elovl3 and Ucp1 in BAT of adult (6 months, n = 4) versus old (18 months, n = 5) mice (left). Photomicrograph of BAT from adult versus old mice. A representative image is shown (right). (b) Network illustration of IPA pathways changes on RNA-Seq based mRNA expression in BAT in NCD-fed (n = 4) versus HFD-fed (n = 4) male C57BL/6 mice. (c) Breeding scheme for the generation of BAT-specific Dicer1 heterozygous knockouts (Dicer1ΔBAT/+). (d) Relative Ucp1 expression in SCAT of Dicer1ΔBAT/+ mice (n = 5) versus control mice (n = 3). If not stated otherwise, boxplots indicate median ± min/max and an unpaired two-tailed Student’s t-test was used to assess statistical significance. *p < 0.05.
