Supplementary Figure 5: Effects of the individual deletion of HS-38 or HS-39 on local chromatin state in primary erythroid cells. | Nature Cell Biology

Supplementary Figure 5: Effects of the individual deletion of HS-38 or HS-39 on local chromatin state in primary erythroid cells.

From: Tissue-specific CTCF–cohesin-mediated chromatin architecture delimits enhancer interactions and function in vivo

Supplementary Figure 5

Normalised ATAC-seq and ChIP-seq read-densities (RPKM; 2 independent experiments in which 2 animals were analysed in total) for H3K27me3, H3K4me3, and CTCF at the α-globin locus in WT, D38 and D39 primary erythroid cells. Shaded grey bar indicates HS-38 and HS-39 (mutated CTCF sites in D38 and D39). The dashed box highlights the region over the Rhbdf1 and Mpg genes, magnified in top panels for ease of data visualisation.

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