Supplementary Figure 3: Differential interactions of α-globin regulatory regions and flanking genes between wild-type and D29 primary erythroid cells. | Nature Cell Biology

Supplementary Figure 3: Differential interactions of α-globin regulatory regions and flanking genes between wild-type and D29 primary erythroid cells.

From: Tissue-specific CTCF–cohesin-mediated chromatin architecture delimits enhancer interactions and function in vivo

Supplementary Figure 3

Capture-C interaction data for the indicated viewpoints (red vertical bars) in wild-type (WT) and CTCF mutant D29 (deletion of HS-29) primary erythroid cells is shown as described in Fig. 2a. Data represent 3 independent experiments in which 3 animals were analysed in total. Shaded grey bar indicates the mutated CTCF site (HS-29). Also shown are normalised CTCF ChIP-seq (RPKM) for both WT and D29 erythroid cells and ATAC-seq (RPKM) for WT erythroid cells, all merged from 2 independent experiments in which 2 animals were analysed. Gene annotation is Refseq.

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