Figure 5: Co-localization of NFI and PPARγ at the brown-fat-specific enhancers.
From: NFIA co-localizes with PPARγ and transcriptionally controls the brown fat gene program
(a) Venn diagram showing the overlap of NFI and PPARγ ChIP-seq peaks in brown adipocytes at day 6 of differentiation. (b) Venn diagram showing the overlap of the co-localizing peaks at day 6 of differentiation, NFI ChIP-seq peaks at day 0 and PPARγ ChIP-seq peaks at day 0. (c) Heat map showing ChIP-seq for NFI, PPARγ, C/EBPα, C/EBPβ, H3K27Ac and ATAC-seq tag densities at the co-localizing peaks of NFI and PPARγ at day 6. (d) Bar graph showing the number of co-localizing sites per gene within ±50 kb of BAT- and WAT-selective genes stratified by the fold changes of gene expression. The genome-wide analyses were performed once on the basis of the ChIP-seq data set.
