Figure 8: Expression of NFIA and the brown-fat-specific genes is positively correlated in perirenal brown fat of human patients with pheochromocytoma.
From: NFIA co-localizes with PPARγ and transcriptionally controls the brown fat gene program
(a) Expression levels of NFIA in perirenal brown fat of human patients with pheochromocytoma or non-functional adrenal tumours (mean ± s.e.m.; n = 7 independent samples for non-functional adrenal tumours and n = 11 independent samples for pheochromocytoma; ∗∗P < 0.01). (b) Correlation of expression of the brown-fat-specific genes and NFIA expression. (c) Expression levels of NFIA in human brown (supraclavicular) and white (abdominal subcutaneous) adipocytes before and after differentiation (mean ± s.e.m.; n = 5 independent samples for white adipocytes and n = 6 independent samples for brown adipocytes; ∗∗P < 0.01). (d) RT-qPCR analysis of NFIA in human neck WAT (subcutaneous) and BAT (carotid sheath) (n = 5 independent samples). The analyses were performed once because human samples were highly limited.
