Figure 10: Proposed model for Hippi/Hip-1 mediated apoptosis. | Nature Cell Biology

Figure 10: Proposed model for Hippi/Hip-1 mediated apoptosis.

From: Recruitment and activation of caspase-8 by the Huntingtin-interacting protein Hip-1 and a novel partner Hippi

Figure 10

Hip-1 is normally bound and sequestered by wild-type Htt (polyglutamine (Q) < 35 residues). Expansion of the Htt polyQ stretch to > 35 residues results in lower affinity for Hip-1, freeing Hip-1 to bind to Hippi. Hippi and Hip-1 form a complex that sequesters procaspase-8 and activates it, presumably by proximity-induced autocatalytic maturation, leading to apoptosis.

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