The unfolding of a mechanically weaker protein domain can be inhibited by inserting it into a stronger domain, creating the possibility of forming multifunctional elastomeric proteins.
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References
Peng, W & Li, H. Domain insertion effectively regulates the mechanical unfolding hierarchy of elastomeric proteins: toward engineering multifunctional elastomeric proteins. J. Am. Chem. Soc. 10.1021/ja903589t (2009).
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Armstrong, G. Proteins get tough. Nature Chem (2009). https://doi.org/10.1038/nchem.414
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DOI: https://doi.org/10.1038/nchem.414
