Desorption electrospray ionization has been used to detect reaction intermediates through mass spectrometry.
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References
Perry, R. H., Splendore, M. Chien, A., Davis, N. K. & Zare, R. N. Detecting reaction intermediates in liquids on the millisecond time scale using desorption electrospray ionization. Angew. Chem. Int. Ed. 10.1002/anie.201004861 (2010).
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Armstrong, G. Investigating intermediates. Nature Chem (2010). https://doi.org/10.1038/nchem.962
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DOI: https://doi.org/10.1038/nchem.962