Inorganic nitrate and nitrite from endogenous or dietary sources are metabolized in vivo to nitric oxide (NO) and other bioactive nitrogen oxides. The nitrate-nitrite-NO pathway is emerging as an important mediator of blood flow regulation, cell signaling, energetics and tissue responses to hypoxia. The latest advances in our understanding of the biochemistry, physiology and therapeutics of nitrate, nitrite and NO were discussed during a recent 2-day meeting at the Nobel Forum, Karolinska Institutet in Stockholm.
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Acknowledgements
This meeting was generously funded by the Department of Physiology and Pharmacology at the Karolinska Institutet, the Vascular Medicine Institute (supported by funds from the Hemophilia Center of Western Pennsylvania and the Institute for Transfusion Medicine) and the Department of Pharmacology and Chemical Biology at the University of Pittsburgh. The meeting was also sponsored by Hope Pharmaceuticals and Ikaria. We are grateful to Elsevier and Nitric Oxide: Biology and Chemistry for kindly printing the meeting abstract book. In addition, we acknowledge generous support from Vinnova (CIDaT), the European Union's 7th Framework Program (FLAVIOLA), and Torsten and Ragnar Söderbergs Foundation. Additional information on speakers and presentations can be found at http://www.strategicresults.com/nitrite/.
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M.T.G., R.P., D.B.K.-S., A.S. and D.J.L. are co-inventors on US National Institutes of Health government patents for the use of nitrite salts for cardiovascular indications and the use of nitrite to detoxify hemoglobin-based oxygen carriers. B.A.F. acknowledges financial interest in Complexa, Inc. J.O.L. and E.W. are listed as co-inventors on three patent applications for the use of inorganic nitrate and nitrite in therapeutics.
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Lundberg, J., Gladwin, M., Ahluwalia, A. et al. Nitrate and nitrite in biology, nutrition and therapeutics. Nat Chem Biol 5, 865–869 (2009). https://doi.org/10.1038/nchembio.260
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DOI: https://doi.org/10.1038/nchembio.260
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