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Protein localization

Can too much lipid glue stop Ras?

Nature Chemical Biology volume 6, pages 483–485 (2010)Cite this article

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The kinetics of the acylation, deacylation and reacylation cycle are important for localization and function of Ras as well as other key signaling proteins. A new small-molecule inhibitor may put the brakes on Ras by inhibiting the deacylation enzyme APT1.

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Figure 1: Palmostatin B, a newly described inhibitor of the deacylating enzyme APT1, enhances Ras palmitoylation and disrupts its subcellular localization.

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Authors and Affiliations

  1. Adrienne D. Cox is in the Departments of Radiation Oncology and Pharmacology and the Lineberger Comprehensive Cancer Center at the University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.,

    Adrienne D Cox

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  1. Adrienne D Cox
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Correspondence to Adrienne D Cox.

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The author declares no competing financial interests.

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Cox, A. Can too much lipid glue stop Ras?. Nat Chem Biol 6, 483–485 (2010). https://doi.org/10.1038/nchembio.399

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