Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Protein folding

Chaperoning protein evolution

Nature Chemical Biology volume 8, pages 226–228 (2012)Cite this article

Subjects

Osmolytes that normally accumulate in cells to equilibrate osmotic stress are also called chemical chaperones because of their ability to stabilize native proteins in vitro. A recent paper shows that various chemical chaperones differently alter the cellular milieu and permit the appearance of osmolyte-specific protein mutant variants during evolution.

Access through your institution
Buy or subscribe

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Access through your institution

Buy this article

  • Purchase on SpringerLink
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Chemical and protein chaperones act as buffers of protein evolution.

References

  1. Yancey, P.H. Exp. Biol. 208, 2819–2830 (2005).

    Article  CAS  Google Scholar 

  2. Diamant, S., Eliahu, N., Rosenthal, D. & Goloubinoff, P. J. Biol. Chem. 276, 39586–39591 (2001).

    Article  CAS  Google Scholar 

  3. Bandyopadhyay, A. et al. Nat. Chem. Biol. 8, 238–245 (2012).

    Article  CAS  Google Scholar 

  4. Anfinsen, C.B. Science 181, 223–230 (1973).

    Article  CAS  Google Scholar 

  5. Sharma, S.K., Christen, P. & Goloubinoff, P. Curr. Protein Pept. Sci. 10, 432–446 (2009).

    Article  CAS  Google Scholar 

  6. Sharma, S.K., De Los Rios, P., Christen, P., Lustig, A. & Goloubinoff, P. Nat. Chem. Biol. 6, 914–920 (2010).

    Article  CAS  Google Scholar 

  7. Tokuriki, N. & Tawfik, D.S. Nature 459, 668–673 (2009).

    Article  CAS  Google Scholar 

  8. Sangster, T.A., Lindquist, S. & Queitsch, C. Bioessays 26, 348–362 (2004).

    Article  CAS  Google Scholar 

  9. Cho, S.S., Reddy, G., Straub, J.E., & Thirumalai, D. J. Phys. Chem. B 115, 13401–13407 (2011).

    Article  CAS  Google Scholar 

  10. Chiti, F. & Dobson, C.M. Annu. Rev. Biochem. 75, 333–366 (2006).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Paolo De Los Rios is in the Laboratory of Statistical Biophysics, Institute of Theoretical Physics, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.,

    Paolo De Los Rios

  2. Pierre Goloubinoff is in the Department of Plant Molecular Biology, Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland.,

    Pierre Goloubinoff

Authors
  1. Paolo De Los Rios
    View author publications

    Search author on:PubMed Google Scholar

  2. Pierre Goloubinoff
    View author publications

    Search author on:PubMed Google Scholar

Corresponding author

Correspondence to Pierre Goloubinoff.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Cite this article

De Los Rios, P., Goloubinoff, P. Chaperoning protein evolution. Nat Chem Biol 8, 226–228 (2012). https://doi.org/10.1038/nchembio.791

Download citation

  • Published:

  • Issue date:

  • DOI: https://doi.org/10.1038/nchembio.791

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing