A powerful technology called global protein stability profiling allows rates of protein turnover to be determined for a substantial fraction of the human proteome in a single experiment. This approach sets the stage for systems-level analyses of the dynamics of the mammalian proteome.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Buy this article
- Purchase on SpringerLink
- Instant access to the full article PDF.
USD 39.95
Prices may be subject to local taxes which are calculated during checkout

Kim Caesar
References
Yen, H.C., Xu, Q., Chou, D.M., Zhao, Z. & Elledge, S.J. Science 322, 918–923 (2008).
Yen, H.C. & Elledge, S.J. Science 322, 923–929 (2008).
Newman, J.R. et al. Nature 441, 840–846 (2006).
Pickart, C.M. & Cohen, R.E. Nat. Rev. Mol. Cell Biol. 5, 177–187 (2004).
Petroski, M.D. & Deshaies, R.J. Nat. Rev. Mol. Cell Biol. 6, 9–20 (2005).
Mann, M. Nat. Rev. Mol. Cell Biol. 7, 952–958 (2006).
Cox, J. & Mann, M. Cell 130, 395–398 (2007).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Ang, X., Harper, J. A road map of cellular protein homeostasis. Nat Chem Biol 5, 9–11 (2009). https://doi.org/10.1038/nchembio0109-9
Issue date:
DOI: https://doi.org/10.1038/nchembio0109-9