Figure 4: SF3B1 mutations in single-cell colonies.
From: SF3B1 mutant MDS-initiating cells may arise from the haematopoietic stem cell compartment
Mutational analysis was performed on BFU-E and CFU-GM colonies derived from primary CD34+ patient cells (MDS1, MDS2, MDS3 and MDS4). Each column represents an individual CFC colony. Circle (MDS1 and MDS2) on the right is the representative of the overall clonality observed in the clonogenic assays (left) in MDS1 and MDS2 and total CD34+ cells. The outer red circle represents the total SF3B1 clone, while the inner circle depicts subclones. WT, wild type.
